Crystal structure of Clostridium perfringens enterotoxin displays features of beta-pore-forming toxins.

@article{Kitadokoro2011CrystalSO,
  title={Crystal structure of Clostridium perfringens enterotoxin displays features of beta-pore-forming toxins.},
  author={Kengo Kitadokoro and Kousuke Nishimura and Shigeki Kamitani and Aya Fukui-Miyazaki and Hirono Toshima and Hiroyuki Abe and Yoichi Kamata and Yoshiko Sugita-Konishi and Shigeki Yamamoto and Hajime Karatani and Yasuhiko Horiguchi},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 22},
  pages={19549-55}
}
Clostridium perfringens enterotoxin (CPE) is a cause of food poisoning and is considered a pore-forming toxin, which damages target cells by disrupting the selective permeability of the plasma membrane. However, the pore-forming mechanism and the structural characteristics of the pores are not well documented. Here, we present the structure of CPE determined by x-ray crystallography at 2.0 Å. The overall structure of CPE displays an elongated shape, composed of three distinct domains, I, II… CONTINUE READING

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