Crystal structure and physicochemical characterization of ambazone monohydrate, anhydrous, and acetate salt solvate.

@article{MuresanPop2014CrystalSA,
  title={Crystal structure and physicochemical characterization of ambazone monohydrate, anhydrous, and acetate salt solvate.},
  author={Marieta Muresan-Pop and Dario Braga and Mihaela Pop and Gheorghe Borodi and Irina Kacso and Lucia Maini},
  journal={Journal of pharmaceutical sciences},
  year={2014},
  volume={103 11},
  pages={
          3594-3601
        }
}
The crystal structures of the monohydrate and anhydrous forms of ambazone were determined by single-crystal X-ray diffraction (SC-XRD). Ambazone monohydrate is characterized by an infinite three-dimensional network involving the water molecules, whereas anhydrous ambazone forms a two-dimensional network via hydrogen bonds. The reversible transformation between the monohydrate and anhydrous forms of ambazone was evidenced by thermal analysis, temperature-dependent X-ray powder diffraction and… 

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