Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D.

Abstract

DNA ligase D (LigD) is a large polyfunctional enzyme involved in nonhomologous end-joining (NHEJ) in mycobacteria. LigD consists of a C-terminal ATP-dependent ligase domain fused to upstream polymerase and phosphoesterase modules. Here we report the 2.4 angstroms crystal structure of the ligase domain of Mycobacterium LigD, captured as the covalent ligase… (More)

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@article{Akey2006CrystalSA, title={Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D.}, author={David Akey and Alexandra Martins and Jideofor Aniukwu and Michael S Glickman and Stewart Shuman and James M Berger}, journal={The Journal of biological chemistry}, year={2006}, volume={281 19}, pages={13412-23} }