Crystal structure and mechanism of a calcium-gated potassium channel

  title={Crystal structure and mechanism of a calcium-gated potassium channel},
  author={Y. Jiang and A. Lee and J. Chen and M. Cad{\`e}ne and B. Chait and R. MacKinnon},
  • Y. Jiang, A. Lee, +3 authors R. MacKinnon
  • Published 2002
  • Medicine, Chemistry
  • Nature
  • Ion channels exhibit two essential biophysical properties; that is, selective ion conduction, and the ability to gate-open in response to an appropriate stimulus. Two general categories of ion channel gating are defined by the initiating stimulus: ligand binding (neurotransmitter- or second-messenger-gated channels) or membrane voltage (voltage-gated channels). Here we present the structural basis of ligand gating in a K+ channel that opens in response to intracellular Ca2+. We have cloned… CONTINUE READING
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