Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.


The three-dimensional structure of the enzyme dihydrodipicolinate synthase (KEGG entry Rv2753c, EC from Mycobacterium tuberculosis (Mtb-DHDPS) was determined and refined at 2.28 A (1 A=0.1 nm) resolution. The asymmetric unit of the crystal contains two tetramers, each of which we propose to be the functional enzyme unit. This is supported by… (More)


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