Crystal structure and biophysical characterization of the nucleoside diphosphate kinase from Leishmania braziliensis


Nucleoside diphosphate kinase (NDK) is a housekeeping enzyme that plays key roles in nucleotide recycling and homeostasis in trypanosomatids. It is also secreted by the intracellular parasite Leishmania to modulate the host response. These functions make NDK an attractive target for drug design and for studies aiming at a better understanding of the… (More)
DOI: 10.1186/s12900-015-0030-8


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