Crystal structure and biochemical studies of the transacting polyketide enoyl reductase LovC from lovastatin biosynthesis

  • Brian D. Amesa, Chi Nguyena, +10 authors Shiou-Chuan Tsaia
  • Published 2012
Lovastatin is an important statin prescribed for the treatment and prevention of cardiovascular diseases. Biosynthesis of lovastatin uses an iterative type I polyketide synthase (PKS). LovC is a transacting enoyl reductase (ER) that specifically reduces three out of eight possible polyketide intermediates during lovastatin biosynthesis. Such trans-acting… CONTINUE READING