Crystal structure and CRISPR RNA-binding site of the Cmr1 subunit of the Cmr interference complex.

@article{Sun2014CrystalSA,
  title={Crystal structure and CRISPR RNA-binding site of the Cmr1 subunit of the Cmr interference complex.},
  author={Jiali Sun and Jae-Hyun Jeon and Minsang Shin and Ho-chul Shin and Byung-Ha Oh and Jeong Sun Kim},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={2014},
  volume={70 Pt 2},
  pages={
          535-43
        }
}
A multi-subunit ribonucleoprotein complex termed the Cmr RNA-silencing complex recognizes and destroys viral RNA in the CRISPR-mediated immune defence mechanism in many prokaryotes using an as yet unclear mechanism. In Archaeoglobus fulgidus, this complex consists of six subunits, Cmr1-Cmr6. Here, the crystal structure of Cmr1 from A. fulgidus is reported, revealing that the protein is composed of two tightly associated ferredoxin-like domains. The domain located at the N-terminus is… CONTINUE READING
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