Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility.

@article{Orans2010CrystalSA,
  title={Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility.},
  author={Jillian Orans and Michael D. Johnson and Kimberly A. Coggan and Justin R Sperlazza and Ryan W. Heiniger and Matthew C Wolfgang and Matthew R. Redinbo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 3},
  pages={1065-70}
}
Several bacterial pathogens require the "twitching" motility produced by filamentous type IV pili (T4P) to establish and maintain human infections. Two cytoplasmic ATPases function as an oscillatory motor that powers twitching motility via cycles of pilus extension and retraction. The regulation of this motor, however, has remained a mystery. We present the 2.1 A resolution crystal structure of the Pseudomonas aeruginosa pilus-biogenesis factor PilY1, and identify a single site on this protein… CONTINUE READING
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