Crystal structure analysis of a complete turn of B-DNA

@article{Wing1980CrystalSA,
  title={Crystal structure analysis of a complete turn of B-DNA},
  author={R. Wing and H. Drew and T. Takano and C. Broka and Shoji Tanaka and K. Itakura and R. Dickerson},
  journal={Nature},
  year={1980},
  volume={287},
  pages={755-758}
}
DNA is probably the most discussed and least observed of all biological macromolecules. Although its role in biology is a central one, with many examples such as operators and restriction sites where specific base sequences have control functions or interact with specific enzymes, the structures that DNA can adopt have been based until now only on sequence-averaged fibre diffraction patterns. Recent improvements in triester synthesis methods have made possible the preparation of sufficient… Expand
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References

SHOWING 1-10 OF 12 REFERENCES
How many base-pairs per turn does DNA have in solution and in chromatin? Some theoretical calculations.
  • M. Levitt
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1978
Calculations on a 20-base pair segment of DNA double helix using empirical energy functions show that DNA can be bent smoothly and uniformly into a superhelix with a small enough radius (45 A) to fitExpand
Helical repeat of DNA in solution.
  • J. Wang
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1979
The helical repeat of DNA in solution has been measured directly by analyzing the gel electrophoretic patterns of pairs of covalently closed DNAs with length differences between 1 and 58 base pairs,Expand
Sequence-specific recognition of double helical nucleic acids by proteins.
TLDR
It is concluded that a single hydrogen bond is inadequate for uniquely identifying any particular base pair, as this leads to numerous degeneracies, but using two hydrogen bonds, fidelity of base pair recognition may be achieved. Expand
Molecular structure of a left-handed double helical DNA fragment at atomic resolution
The DNA fragment d(CpGpCpGpCpG) crystallises as a left-handed double helical molecule with Watson–Crick base pairs and an antiparallel organisation of the sugar phosphate chains. The helix has twoExpand
Flexibility of DNA
TLDR
A model for the flexibility of DNA is proposed that is based on discrete variations in the direction of propagation in going from one subunit to the next, which gives a Gaussian distribution function. Expand
High-salt d(CpGpCpG), a left-handed Z′ DNA double helix
The DNA tetramer d(CpGpCpG) or CGCG crystallizes from high-salt solution as a left-handed double helix, the Z′ helix. Its structure differs from that of the other known left-handed helix, Z-DNA, by aExpand
A simple model of DNA superhelices in solution.
TLDR
A very simple model of such a superhelix in which twisting and bending forces are in balance is described, subject both to topological constraints and to a limitation on the distance of closet approach of the interwound duplexes of thesuperhelix. Expand
Transient electric dichroism of rod-like DNA molecules.
TLDR
The results establish transient electric dichroism measurements as a technique well suited for study of alterations in the length and base pair inclination of rod-like DNA molecules. Expand
Refinement of Large Structures by Simultaneous Minimization of Energy and R Factor
An improved method of crystallographic structure refinement, especially suitable for large molecules, is described, it is based on simultaneous minimization of a realistic potential-energy functionExpand
Cancer chemotherapy handbook
TLDR
This book contains information on the biotechnology agents for cancer treatment and support and the use of new recombinant proteins. Expand
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