Crystal-induced Inflammation in Canine Joints

@article{Phelps1966CrystalinducedII,
  title={Crystal-induced Inflammation in Canine Joints},
  author={Paulding Phelps and Daniel J Mccarty},
  journal={The Journal of Experimental Medicine},
  year={1966},
  volume={124},
  pages={99 - 114}
}
Injection of sodium urate or calcium pyrophosphate crystals into the stifle joints of anesthetized dogs almost invariably induced an acute exudative response. This response was quantified by serial measurements of intra-articular pressure, pH and leukocyte concentration. Pressure rose progressively and reflected intra-articular volume increase. The hydrogen ion concentration increased as the reaction progressed and correlated in a given exudate with the leukocyte concentration. Analysis of… CONTINUE READING

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The significance of calcium phosphate crystals in the synovial fluid of arthritic patients, "the pseudogout syndrome

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4 Excerpts

Crystal - induced inflammation in canine joints . I . An experimental model with quantification of the host response

  • D. J. McCarty, P. Phelps, J. Pyenson
  • J . Exp . Med .
  • 1966

Crystal - induced inflammation in canine joints II . Importance of polymorphonuclear leukocytes

  • P. Phelps, D. J McCarty
  • J . Exp . Med .
  • 1966

An English translation with comments

  • M. Freudweiler
  • Ann . Internal Med .
  • 1964

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