Crystal engineering of novel cocrystals of a triazole drug with 1,4-dicarboxylic acids.

@article{Remenar2003CrystalEO,
  title={Crystal engineering of novel cocrystals of a triazole drug with 1,4-dicarboxylic acids.},
  author={Julius F. Remenar and Sherry Morissette and Matthew L. Peterson and Brian Moulton and J Michael MacPhee and H{\'e}ctor R Guzm{\'a}n and Orn Almarsson},
  journal={Journal of the American Chemical Society},
  year={2003},
  volume={125 28},
  pages={8456-7}
}
Cocrystals of the poorly soluble antifungal drug cis-itraconazole (1) with 1,4-dicarboxylic acids have been prepared. The crystal structure of the succinic acid cocrystal with 1 was determined to be a trimer by single-crystal X-ray. The trimer is comprised of two molecules of 1 oriented in antiparallel fashion to form a pocket with a triazole at either end. The extended succinic acid molecule fills the pocket, bridging the triazole groups through hydrogen-bonding interactions rather than… CONTINUE READING

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