Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs

@inproceedings{Eswaran2007CrystalSO,
  title={Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs},
  author={Jeyanthy Eswaran and Wen Hwa Lee and Judit {\'E}. Debreczeni and Panagis Filippakopoulos and Andrew Alfred Turnbull and Oleg Fedorov and Sean William Deacon and Jeffrey R Peterson and Stefan Knapp},
  booktitle={Structure},
  year={2007}
}
p21-activated kinases have been classified into two groups based on their domain architecture. Group II PAKs (PAK4-6) regulate a wide variety of cellular functions, and PAK deregulation has been linked to tumor development. Structural comparison of five high-resolution structures comprising all active, monophosphorylated group II catalytic domains revealed a surprising degree of domain plasticity, including a number of catalytically productive and nonproductive conformers. Rearrangements of… CONTINUE READING
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