Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis


Npro is a key effector protein of pestiviruses such as bovine viral diarrhea virus and abolishes host cell antiviral defense mechanisms. Synthesized as the N-terminal part of the viral polyprotein, Npro releases itself via an autoproteolytic cleavage, triggering its immunological functions. However, the mechanisms of its proteolytic action and its immune… (More)
DOI: 10.1016/j.str.2013.04.003


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