Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78

@inproceedings{Winiewska2010CrystalSO,
  title={Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78},
  author={Magdalena Wiśniewska and Tobias Karlberg and Lari Lehti{\"o} and Ida Johansson and Tetyana Kotenyova and Martin Moche and Herwig Sch{\"u}ler},
  booktitle={PloS one},
  year={2010}
}
UNLABELLED The 70-kDa heat shock proteins (Hsp70) are chaperones with central roles in processes that involve polypeptide remodeling events. Hsp70 proteins consist of two major functional domains: an N-terminal nucleotide binding domain (NBD) with ATPase activity, and a C-terminal substrate binding domain (SBD). We present the first crystal structures of… CONTINUE READING