Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family

@article{Mills2016CrystalSO,
  title={Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family},
  author={S. Mills and C. Silvander and G. Cozier and L. Tr{\'e}saugues and P. Nordlund and B. Potter},
  journal={Biochemistry},
  year={2016},
  volume={55},
  pages={1384 - 1397}
}
  • S. Mills, C. Silvander, +3 authors B. Potter
  • Published 2016
  • Chemistry, Medicine
  • Biochemistry
  • The inositol polyphosphate 5-phosphatase INPP5B hydrolyzes the 5-phosphate group from water- and lipid-soluble signaling messengers. Two synthetic benzene and biphenyl polyphosphates (BzP/BiPhPs), simplified surrogates of inositol phosphates and phospholipid headgroups, were identified by thermodynamic studies as potent INPP5B ligands. The X-ray structure of the complex between INPP5B and biphenyl 3,3′,4,4′,5,5′-hexakisphosphate [BiPh(3,3′,4,4′,5,5′)P6, IC50 5.5 μM] was determined at 2.89… CONTINUE READING
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