Crystal Structure of the protein drug urate oxidase-inhibitor complex at 2.05 Å resolution

  title={Crystal Structure of the protein drug urate oxidase-inhibitor complex at 2.05 {\AA} resolution},
  author={N. Colloc'h and M. E. Hajji and B. Bachet and G. L'hermite and M. Schiltz and T. Prang{\'e} and B. Castro and J. Mornon},
  journal={Nature Structural Biology},
  • N. Colloc'h, M. E. Hajji, +5 authors J. Mornon
  • Published 1997
  • Chemistry, Medicine
  • Nature Structural Biology
  • The gene coding for urate oxidase, an enzyme that catalyzes the oxidation of uric acid to allantoin, is inactivated in humans. Consequently, urate oxidase is used as a protein drug to overcome severe disorders induced by uric acid accumulation. The structure of the active homotetrameric enzyme reveals the existence of a small architectural domain that we call T-fold (for tunnelling-fold) domain. It assembles to form a perfect unusual dimeric α8β16 barrel. Urate oxidase may be the archetype of… CONTINUE READING
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