Crystal Structure of the Vanadate-Inhibited Ca(2+)-ATPase.

  title={Crystal Structure of the Vanadate-Inhibited Ca(2+)-ATPase.},
  author={Johannes D. Clausen and Maike Bublitz and Bertrand Arnou and Claus Olesen and Jens P Andersen and Jesper Vuust M\oller and Poul Nissen},
  volume={24 4},
Vanadate is the hallmark inhibitor of the P-type ATPase family; however, structural details of its inhibitory mechanism have remained unresolved. We have determined the crystal structure of sarcoplasmic reticulum Ca(2+)-ATPase with bound vanadate in the absence of Ca(2+). Vanadate is bound at the catalytic site as a planar VO3(-) in complex with water and Mg(2+) in a dephosphorylation transition-state-like conformation. Validating bound VO3(-) by anomalous difference Fourier maps using long… CONTINUE READING



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