Crystal Structure of the Vanadate-Inhibited Ca(2+)-ATPase.


Vanadate is the hallmark inhibitor of the P-type ATPase family; however, structural details of its inhibitory mechanism have remained unresolved. We have determined the crystal structure of sarcoplasmic reticulum Ca(2+)-ATPase with bound vanadate in the absence of Ca(2+). Vanadate is bound at the catalytic site as a planar VO3(-) in complex with water and… (More)
DOI: 10.1016/j.str.2016.02.018