Crystal Structure of the Rabies Virus Nucleoprotein-RNA Complex
@article{Albertini2006CrystalSO, title={Crystal Structure of the Rabies Virus Nucleoprotein-RNA Complex}, author={Aur{\'e}lie A Albertini and Amy K. Wernimont and Tadeusz Mikołaj Muzioł and Raimond B. G. Ravelli and Cedric R. Clapier and Guy Schoehn and Winfried Weissenhorn and Rob W. H. Ruigrok}, journal={Science}, year={2006}, volume={313}, pages={360 - 363} }
Negative-strand RNA viruses condense their genome into a helical nucleoprotein-RNA complex, the nucleocapsid, which is packed into virions and serves as a template for the RNA-dependent RNA polymerase complex. The crystal structure of a recombinant rabies virus nucleoprotein-RNA complex, organized in an undecameric ring, has been determined at 3.5 angstrom resolution. Polymerization of the nucleoprotein is achieved by domain exchange between protomers, with flexible hinges allowing nucleocapsid…
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