Crystal Structure of the Minor Pilin CofB, the Initiator of CFA/III Pilus Assembly in Enterotoxigenic Escherichia coli.

@article{Kolappan2015CrystalSO,
  title={Crystal Structure of the Minor Pilin CofB, the Initiator of CFA/III Pilus Assembly in Enterotoxigenic Escherichia coli.},
  author={Subramania Kolappan and Dixon Ng and Guixiang Yang and Tony Harn and Lisa Craig},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 43},
  pages={
          25805-18
        }
}
Type IV pili are extracellular polymers of the major pilin subunit. These subunits are held together in the pilus filament by hydrophobic interactions among their N-terminal α-helices, which also anchor the pilin subunits in the inner membrane prior to pilus assembly. Type IV pilus assembly involves a conserved group of proteins that span the envelope of Gram-negative bacteria. Among these is a set of minor pilins, so named because they share their hydrophobic N-terminal polymerization/membrane… CONTINUE READING
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