Crystal Structure of the Long-Chain Fatty Acid Transporter FadL

@article{vandenBerg2004CrystalSO,
  title={Crystal Structure of the Long-Chain Fatty Acid Transporter FadL},
  author={Bert van den Berg and Paul N. Black and William M. Clemons and Tom A. Rapoport},
  journal={Science},
  year={2004},
  volume={304},
  pages={1506 - 1509}
}
The mechanisms by which hydrophobic molecules, such as long-chain fatty acids, enter cells are poorly understood. In Gram-negative bacteria, the lipopolysaccharide layer in the outer membrane is an efficient barrier for fatty acids and aromatic hydrocarbons destined for biodegradation. We report crystal structures of the long-chain fatty acid transporter FadL from Escherichia coli at 2.6 and 2.8 angstrom resolution. FadL forms a 14-stranded β barrel that is occluded by a central hatch domain… 
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