# Crystal Structure of the Interleukin-4/Receptor α Chain Complex Reveals a Mosaic Binding Interface

@article{Hage1999CrystalSO,
title={Crystal Structure of the Interleukin-4/Receptor $\alpha$ Chain Complex Reveals a Mosaic Binding Interface},
author={T. Hage and W. Sebald and P. Reinemer},
journal={Cell},
year={1999},
volume={97},
pages={271-281}
}
• Published 1999
• Biology, Medicine
• Cell
Interleukin-4 (IL-4) is a principal regulatory cytokine during an immune response and a crucial determinant for allergy and asthma. IL-4 binds with high affinity and specificity to the ectodomain of the IL-4 receptor alpha chain (IL4-BP). Subsequently, this intermediate complex recruits the common gamma chain (gamma c), thereby initiating transmembrane signaling. The crystal structure of the intermediate complex between human IL-4 and IL4-BP was determined at 2.3 A resolution. It reveals a… Expand
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