Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

@article{Xiong2002CrystalSO,
  title={Crystal Structure of the Extracellular Segment of Integrin $\alpha$V$\beta$3 in Complex with an Arg-Gly-Asp Ligand},
  author={Jian-ping Xiong and Thilo Stehle and Rongguang Zhang and Andrzej J Joachimiak and Matthias Frech and Simon L. Goodman and M. Amin Arnaout},
  journal={Science},
  year={2002},
  volume={296},
  pages={151 - 155}
}
The structural basis for the divalent cation–dependent binding of heterodimeric αβ integrins to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown. Interaction with ligands triggers tertiary and quaternary structural rearrangements in integrins that are needed for cell signaling. Here we report the crystal structure of the extracellular segment of integrin αVβ3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence. The ligand binds at the major… 
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