Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1

@article{Rabl2011CrystalSO,
  title={Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1},
  author={Julius Rabl and Marc Leibundgut and Sandro F. Ataide and Andrea Haag and Nenad Ban},
  journal={Science},
  year={2011},
  volume={331},
  pages={730 - 736}
}
The structure provides insight into how protein synthesis is initiated and into the evolution of the eukaryotic ribosome. Eukaryotic ribosomes are substantially larger and more complex than their bacterial counterparts. Although their core function is conserved, bacterial and eukaryotic protein synthesis differ considerably at the level of initiation. The eukaryotic small ribosomal subunit (40S) plays a central role in this process; it binds initiation factors that facilitate scanning of… 

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The crystal structure of the yeast 80S ribosome determined at 4.15 angstrom resolution reveals the higher complexity of eukaryotic ribosomes, which are 40% larger than their bacterial counterparts.

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