Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA

@inproceedings{Yap2010CrystalSO,
  title={Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA},
  author={Li Jian Yap and Dahai Luo and Ka Yan Chung and Siew Pheng Lim and Christophe Bodenreider and Christian Guy Noble and Pei-Yong Shi and Julien Lescar},
  booktitle={PloS one},
  year={2010}
}
The N-terminal domain of the flavivirus NS5 protein functions as a methyltransferase (MTase). It sequentially methylates the N7 and 2'-O positions of the viral RNA cap structure (GpppA→(7me)GpppA→(7me)GpppA(2'-O-me)). The same NS5 domain could also have a guanylyltransferase activity (GTP+ppA-RNA→GpppA). The mechanism by which this protein domain catalyzes these three distinct functions is currently unknown. Here we report the crystallographic structure of DENV-3 MTase in complex with a 5… CONTINUE READING
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The flavivirus NS 5 protein is a true

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