Crystal Structure of an IHF-DNA Complex: A Protein-Induced DNA U-Turn

@article{Rice1996CrystalSO,
  title={Crystal Structure of an IHF-DNA Complex: A Protein-Induced DNA U-Turn},
  author={Phoebe A Rice and Shu-wei Yang and Kiyoshi Mizuuchi and Howard A. Nash},
  journal={Cell},
  year={1996},
  volume={87},
  pages={1295-1306}
}
Integration host factor (IHF) is a small heterodimeric protein that specifically binds to DNA and functions as an architectural factor in many cellular processes in prokaryotes. Here, we report the crystal structure of IHF complexed with 35 bp of DNA. The DNA is wrapped around the protein and bent by >160 degrees, thus reversing the direction of the helix axis within a very short distance. Much of the bending occurs at two large kinks where the base stacking is interrupted by intercalation of a… CONTINUE READING
BETA

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 243 CITATIONS

FILTER CITATIONS BY YEAR

1997
2019

CITATION STATISTICS

  • 25 Highly Influenced Citations

  • Averaged 10 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

The interpretation of protein structure : estimation of static accessibility

  • F. M Richards
  • J . Mol . Biol .
  • 1971
Highly Influential
1 Excerpt

Intercala - structure of an oligo ( dA ) · oligo ( dT ) tract and its biological implication , DNA kinking , and the control of transcription

  • M. H. The Werner, A. M. Gronenborn, G. M. Clore
  • Science 271 , tions . Nature
  • 1996

Similar Papers

Loading similar papers…