Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K+ Channel

  title={Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K+ Channel},
  author={S. B. Long and E. Campbell and R. MacKinnon},
  pages={897 - 903}
  • S. B. Long, E. Campbell, R. MacKinnon
  • Published 2005
  • Chemistry, Medicine
  • Science
  • Voltage-dependent potassium ion (K+) channels (Kv channels) conduct K+ ions across the cell membrane in response to changes in the membrane voltage, thereby regulating neuronal excitability by modulating the shape and frequency of action potentials. Here we report the crystal structure, at a resolution of 2.9 angstroms, of a mammalian Kv channel, Kv1.2, which is a member of the Shaker K+ channel family. This structure is in complex with an oxido-reductase β subunit of the kind that can regulate… CONTINUE READING
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