Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K+ Channel
@article{Long2005CrystalSO, title={Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K+ Channel}, author={S. B. Long and E. Campbell and R. MacKinnon}, journal={Science}, year={2005}, volume={309}, pages={897 - 903} }
Voltage-dependent potassium ion (K+) channels (Kv channels) conduct K+ ions across the cell membrane in response to changes in the membrane voltage, thereby regulating neuronal excitability by modulating the shape and frequency of action potentials. Here we report the crystal structure, at a resolution of 2.9 angstroms, of a mammalian Kv channel, Kv1.2, which is a member of the Shaker K+ channel family. This structure is in complex with an oxido-reductase β subunit of the kind that can regulate… CONTINUE READING
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References
SHOWING 1-10 OF 78 REFERENCES
Crystal structure and mechanism of a calcium-gated potassium channel
- Chemistry, Medicine
- Nature
- 2002
- 1,299
- PDF
Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling
- Chemistry, Medicine
- Science
- 2005
- 902
- PDF
Functional analysis of an archaebacterial voltage-dependent K+ channel
- Biology, Medicine
- Nature
- 2003
- 200
- PDF
Blocker protection in the pore of a voltage-gated K+ channel and its structural implications
- Chemistry, Medicine
- Nature
- 2000
- 348
- PDF
Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit
- Chemistry, Medicine
- Nature
- 1994
- 820
Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels.
- Chemistry, Medicine
- Science
- 2000
- 294
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges
- Chemistry, Medicine
- Nature
- 2004
- 199
- PDF