Crystal Structure of a Homolog of Mammalian Serine Racemase from Schizosaccharomyces pombe*

@article{Goto2009CrystalSO,
  title={Crystal Structure of a Homolog of Mammalian Serine Racemase from Schizosaccharomyces pombe*},
  author={M. Goto and T. Yamauchi and N. Kamiya and I. Miyahara and T. Yoshimura and H. Mihara and T. Kurihara and K. Hirotsu and N. Esaki},
  journal={The Journal of Biological Chemistry},
  year={2009},
  volume={284},
  pages={25944 - 25952}
}
d-Serine is an endogenous coagonist for the N-methyl-d-aspartate receptor and is involved in excitatory neurotransmission in the brain. Mammalian pyridoxal 5′-phosphate-dependent serine racemase, which is localized in the mammalian brain, catalyzes the racemization of l-serine to yield d-serine and vice versa. The enzyme also catalyzes the dehydration of d- and l-serine. Both reactions are enhanced by Mg·ATP in vivo. We have determined the structures of the following three forms of the… Expand
Crystal Structure of Serine Racemase that Produces Neurotransmitter D-Serine for Stimulation of the NMDA Receptor
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TLDR
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