Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements

@article{Korostelev2006CrystalSO,
  title={Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements},
  author={A. Korostelev and S. Trakhanov and M. Laurberg and H. Noller},
  journal={Cell},
  year={2006},
  volume={126},
  pages={1065-1077}
}
Our understanding of the mechanism of protein synthesis has undergone rapid progress in recent years as a result of low-resolution X-ray and cryo-EM structures of ribosome functional complexes and high-resolution structures of ribosomal subunits and vacant ribosomes. Here, we present the crystal structure of the Thermus thermophilus 70S ribosome containing a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of the interactions between the ribosome, tRNA, and mRNA in the P… Expand
View on Elsevier
doi.org
500 Citations
Highly Influential Citations
29
Background Citations
192
Methods Citations
17
Results Citations
6

500 Citations

Citation Type

Citation Type

The ribosome in focus: new structures bring new insights.
Insights into protein biosynthesis from structures of bacterial ribosomes.
  • V. Berk, J. Cate
  • Biology, Medicine
  • Current opinion in structural biology
  • 2007
Interactions of the ribosome with mRNA and tRNA.
Structures of yeast 80S ribosome-tRNA complexes in the rotated and nonrotated conformations.
Structural Studies of the Functional Complexes of the 50S and 70S Ribosome, a Major Antibiotic Target
Crystal structure of the ribosome recycling factor bound to the ribosome
Structure of the mammalian 80S ribosome at 8.7 A resolution.
Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome
Structures of the Ribosome in Intermediate States of Ratcheting
Crystal Structures of EF-G–Ribosome Complexes Trapped in Intermediate States of Translocation
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 90 REFERENCES
X-ray crystal structures of 70S ribosome functional complexes.
Crystal Structure of the Ribosome at 5.5 Å Resolution
Structure of the 30S ribosomal subunit
Identification of molecular interactions between P-site tRNA and the ribosome essential for translocation
  • J. Feinberg, S. Joseph
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon
Structures of the Bacterial Ribosome at 3.5 Å Resolution
Ribosomes and translation.
Function of the ribosomal E-site: a mutagenesis study
Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form
A ratchet-like inter-subunit reorganization of the ribosome during translocation
...
1
2
3
4
5
...