Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements

@article{Korostelev2006CrystalSO,
  title={Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements},
  author={A. Korostelev and S. Trakhanov and M. Laurberg and H. Noller},
  journal={Cell},
  year={2006},
  volume={126},
  pages={1065-1077}
}
Our understanding of the mechanism of protein synthesis has undergone rapid progress in recent years as a result of low-resolution X-ray and cryo-EM structures of ribosome functional complexes and high-resolution structures of ribosomal subunits and vacant ribosomes. Here, we present the crystal structure of the Thermus thermophilus 70S ribosome containing a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of the interactions between the ribosome, tRNA, and mRNA in the P… Expand
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