Crystal Structure of OXA-58 with the Substrate-Binding Cleft in a Closed State: Insights into the Mobility and Stability of the OXA-58 Structure

Abstract

OXA-58 is a class D β-lactamase from the multi-drug resistant Acinetobacter baumannii. We determined the crystal structure of OXA-58 in a novel crystal, and revealed the structure of the substrate-binding cleft in a closed state, distinct from a previously reported OXA-58 crystal structure with the binding cleft in an open state. In the closed state, the… (More)
DOI: 10.1371/journal.pone.0145869

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@inproceedings{Saino2015CrystalSO, title={Crystal Structure of OXA-58 with the Substrate-Binding Cleft in a Closed State: Insights into the Mobility and Stability of the OXA-58 Structure}, author={Hiromichi Saino and Tomohiro Sugiyabu and Go Ueno and Masaki Yamamoto and Yoshikazu Ishii and Masashi Miyano and Hendrik W van Veen}, booktitle={PloS one}, year={2015} }