Crystal Structure of Negative Cofactor 2 Recognizing the TBP-DNA Transcription Complex

@article{Kamada2001CrystalSO,
  title={Crystal Structure of Negative Cofactor 2 Recognizing the TBP-DNA Transcription Complex},
  author={Katsuhiko Kamada and Fong Shu and Hua Chen and Sohail Malik and Gertraud Stelzer and Robert G Roeder and Michael Meisterernst and Stephen K. Burley},
  journal={Cell},
  year={2001},
  volume={106},
  pages={71-81}
}
The X-ray structure of a ternary complex of Negative Cofactor 2 (NC2), the TATA box binding protein (TBP), and DNA has been determined at 2.6 A resolution. The N termini of NC2 alpha and beta resemble histones H2A and H2B, respectively, and form a heterodimer that binds to the bent DNA double helix on the underside of the preformed TBP-DNA complex via electrostatic interactions. NC2beta contributes to inhibition of TATA-dependent transcription through interactions of its C-terminal alpha helix… CONTINUE READING
43 Citations
51 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Functional dissection

  • K. Luger, A. W. Mader, +4 authors D. Reinberg
  • 1997
Highly Influential
6 Excerpts

The protein structures and structural meaning of sequence alignment

  • P. F. Kosa, G. Ghosh, B. S. DeDecker, P. B. Sigler
  • 2 . 1 Å crystal structure of an arachael…
  • 1997
Highly Influential
8 Excerpts

AMoRe: an automated package for molecular

  • J. Navaza
  • 1994
Highly Influential
4 Excerpts

DRAP1/NC2a homolog that has both positive and negative roles

  • S. Kim, J. G. Na, M. Hampsey, D. Reinberg
  • 1997
Highly Influential
4 Excerpts

AMoRe : an automated package for molecularA mechanism for repression of class II gene transcription through replacement

  • J. Navaza
  • Acta Crystallogr . A EMBO J .
  • 1994
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…