Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II

  title={Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II},
  author={Fei Sun and Xia Huo and Yujia Zhai and Aojin Wang and Jianxing Xu and Dan Su and Mark Bartlam and Zihe Rao},
The mitochondrial respiratory Complex II or succinate:ubiquinone oxidoreductase (SQR) is an integral membrane protein complex in both the tricarboxylic acid cycle and aerobic respiration. Here we report the first crystal structure of Complex II from porcine heart at 2.4 A resolution and its complex structure with inhibitors 3-nitropropionate and 2-thenoyltrifluoroacetone (TTFA) at 3.5 A resolution. Complex II is comprised of two hydrophilic proteins, flavoprotein (Fp) and iron-sulfur protein… CONTINUE READING
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