Crystal Structure of Human DNA Methyltransferase 1.

@article{Zhang2015CrystalSO,
  title={Crystal Structure of Human DNA Methyltransferase 1.},
  author={Zhi-Min Zhang and Shuguang Liu and Krystal Lin and Youfu Luo and John Jefferson Piers Perry and Yinsheng Wang and Jikui Song},
  journal={Journal of molecular biology},
  year={2015},
  volume={427 15},
  pages={
          2520-2531
        }
}
DNMT1 (DNA methyltransferase 1) is responsible for propagating the DNA methylation patterns during DNA replication. DNMT1 contains, in addition to a C-terminal methyltransferase domain, a large N-terminal regulatory region that is composed of an RFTS (replication foci targeting sequence) domain, a CXXC zinc finger domain and a pair of BAH (bromo adjacent homology) domains. The regulatory domains of DNMT1 mediate a network of protein-protein and protein-DNA interactions to control the… CONTINUE READING

Tables and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 42 REFERENCES

Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1).

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2011
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL