Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.

@article{Mahon2018CrystalSO,
  title={Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.},
  author={Brian P Mahon and Sriram Ambadapadi and Jordan R Yaron and Carrie L Lomelino and Melissa A Pinard and Shahar Keinan and Igor Kurnikov and Colin Macaulay and Liqiang Zhang and Westley H. Reeves and Grant Mcfadden and Scott A Tibbetts and Robert McKenna and Alexandra R Lucas},
  journal={Biochemistry},
  year={2018},
  volume={57 7},
  pages={1096-1107}
}
The Myxomavirus-derived protein Serp-1 has potent anti-inflammatory activity in models of vasculitis, lupus, viral sepsis, and transplant. Serp-1 has also been tested successfully in a Phase IIa clinical trial in unstable angina, representing a "first-in-class" therapeutic. Recently, peptides derived from the reactive center loop (RCL) have been developed as stand-alone therapeutics for reducing vasculitis and improving survival in MHV68-infected mice. However, both Serp-1 and the RCL peptides… CONTINUE READING