Crystal Structure and Functional Analysis of the HERG Potassium Channel N Terminus A Eukaryotic PAS Domain

@article{Cabral1998CrystalSA,
  title={Crystal Structure and Functional Analysis of the HERG Potassium Channel N Terminus A Eukaryotic PAS Domain},
  author={Jo{\~a}o H.Morais Cabral and Alec John Lee and Steven L. Cohen and Brian T Chait and Min Li and Roderick MacKinnon},
  journal={Cell},
  year={1998},
  volume={95},
  pages={649-655}
}
The HERG voltage-dependent K+ channel plays a role in cardiac electrical excitability, and when defective, it underlies one form of the long QT syndrome. We have determined the crystal structure of the HERG K+ channel N-terminal domain and studied its role as a modifier of gating using electrophysiological methods. The domain is similar in structure to a bacterial light sensor photoactive yellow protein and provides the first three-dimensional model of a eukaryotic PAS domain. Scanning… CONTINUE READING
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