Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex

@inproceedings{Decroly2011CrystalSA,
  title={Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex},
  author={Etienne Decroly and Claire Debarnot and François Ferron and Mickael Bouvet and Bruno Coutard and Isabelle Imbert and Laure Gluais and Nicolas Papageorgiou and Andrew J. Sharff and Gerard Bricogne and Miguel Ortiz-Lombard{\'i}a and Julien Lescar and Bruno Canard},
  booktitle={PLoS pathogens},
  year={2011}
}
Cellular and viral S-adenosylmethionine-dependent methyltransferases are involved in many regulated processes such as metabolism, detoxification, signal transduction, chromatin remodeling, nucleic acid processing, and mRNA capping. The Severe Acute Respiratory Syndrome coronavirus nsp16 protein is a S-adenosylmethionine-dependent (nucleoside-2'-O)-methyltransferase only active in the presence of its activating partner nsp10. We report the nsp10/nsp16 complex structure at 2.0 Å resolution, which… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 62 references

Molecular mapping of the RNA Cap 29-O-methyltransferase activation interface between SARS coronavirus nsp10 and nsp16

  • A Lugari, S Betzi, E Decroly, E Bonnaud, A Hermant
  • J Biol Chem
  • 2010
Highly Influential
10 Excerpts

Distributing Many Points on a Sphere

  • EB Saff, ABJ Kuijlaars
  • Math Intell
  • 1997
Highly Influential
2 Excerpts

Similar Papers

Loading similar papers…