Crystal-Structure-Guided Design of Self-Assembling RNA Nanotriangles.

  title={Crystal-Structure-Guided Design of Self-Assembling RNA Nanotriangles.},
  author={Mark A Boerneke and Sergey M. Dibrov and Thomas Hermann},
  journal={Angewandte Chemie},
  volume={55 12},
RNA nanotechnology uses RNA structural motifs to build nanosized architectures that assemble through selective base-pair interactions. Herein, we report the crystal-structure-guided design of highly stable RNA nanotriangles that self-assemble cooperatively from short oligonucleotides. The crystal structure of an 81 nucleotide nanotriangle determined at 2.6 Å resolution reveals the so-far smallest circularly closed nanoobject made entirely of double-stranded RNA. The assembly of the nanotriangle… CONTINUE READING
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