Cryptosporidium parvum Infection in SCID Mice Infected with Only One Oocyst: qPCR Assessment of Parasite Replication in Tissues and Development of Digestive Cancer

@inproceedings{Benamrouz2012CryptosporidiumPI,
  title={Cryptosporidium parvum Infection in SCID Mice Infected with Only One Oocyst: qPCR Assessment of Parasite Replication in Tissues and Development of Digestive Cancer},
  author={Sadia Benamrouz and Karine Guyot and Sophie Gazzola and Anthony Mouray and Thierry Chassat and Baptiste Delaire and Magali Chab{\'e} and Pierre Gosset and Eric Viscogliosi and Eduardo Dei-Cas and Colette Creusy and Val{\'e}rie Conseil and Gabriela Certad},
  booktitle={PloS one},
  year={2012}
}
Dexamethasone (Dex) treated Severe Combined Immunodeficiency (SCID) mice were previously described as developing digestive adenocarcinoma after massive infection with Cryptosporidium parvum as soon as 45 days post-infection (P.I.). We aimed to determine the minimum number of oocysts capable of inducing infection and thereby gastrointestinal tumors in this model. Mice were challenged with calibrated oocyst suspensions containing intended doses of: 1, 10, 100 or 10(5) oocysts of C. parvum Iowa… CONTINUE READING

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