Cryptosporidium parvum: intensity of infection and oocyst excretion patterns in healthy volunteers.

@article{Chappell1996CryptosporidiumPI,
  title={Cryptosporidium parvum: intensity of infection and oocyst excretion patterns in healthy volunteers.},
  author={C. Chappell and P. Okhuysen and C. Sterling and H. DuPont},
  journal={The Journal of infectious diseases},
  year={1996},
  volume={173 1},
  pages={
          232-6
        }
}
Data about human Cryptosporidium parvum infection have originated from travelers, community and day care center outbreaks, and persons infected with the human immunodeficiency virus. In addition, experimental infection in 29 antibody-negative, healthy, adult volunteers generated information on the dose-infection response of C. parvum (Iowa strain). In that report, low inocula were sufficient to cause infection in 18 and illness in 7 persons. To further define the duration and intensity of… Expand
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References

SHOWING 1-10 OF 19 REFERENCES
Intensity of infection in AIDS-associated cryptosporidiosis.
TLDR
A fluorescent monoclonal anti-Cryptosporidium antibody was used to count the oocysts in stools of 12 AIDS patients with chronic cryptosporidiosis and there was a significant correlation between oocyst excretion and numbers of Cryptospora organisms seen on small bowel biopsy. Expand
Cryptosporidiosis: clinical features and diagnosis.
TLDR
Screening for this organism may become very important in known risk groups (animal handlers; children, staff members, and contacts of those who attend day care centers; travelers; and those who are immunodeficient), particularly if an effective therapy is found. Expand
Human cryptosporidiosis.
TLDR
In HIV-infected patients with cryptosporidiosis, antiretroviral therapy should be instituted or modified, and non-specific therapy with antidiarrhoeal agents should also be instituted. Expand
Large community outbreak of cryptosporidiosis due to contamination of a filtered public water supply.
TLDR
Current standards for the treatment of public water supplies may not prevent the contamination of drinking water by Cryptosporidium, with consequent outbreaks of cryptosporidiosis, it is concluded. Expand
Giardia lamblia and Cryptosporidium infections in child day‐care centers in Fulton County, Georgia
TLDR
Day‐care centers with a Giardia‐positive child in 1986 were not more likely to have an infected child in 1989 to 1990, and Cryptosporidium, like Giardsia, may be endemic in day‐care Centers in Fulton County. Expand
A massive outbreak in Milwaukee of cryptosporidium infection transmitted through the public water supply.
TLDR
This massive outbreak of watery diarrhea among the residents of Milwaukee was caused by cryptosporidium oocysts that passed through the filtration system of one of the city's water-treatment plants, and water-quality standards and the testing of patients for cryptOSporidium were not adequate to detect this outbreak. Expand
Cryptosporidiosis in child care settings: a review of the literature and recommendations for prevention and control.
TLDR
Understanding of the epidemiology of cryptosporidiosis in child care settings is hampered by the lack of information from both cross-sectional and prospective studies, and control strategies for specific pathogens should be evaluated. Expand
Cryptosporidium and Cryptosporidiosis
TLDR
This chapter provides an up to date review of the biology, biochemistry and host parasite relationships of Cryptosporidium. Expand
Intestinal infections in patients with the acquired immunodeficiency syndrome (AIDS). Etiology and response to therapy.
TLDR
Thorough diagnostic evaluation can lead to the identification of enteric pathogens in a high percentage of patients with AIDS and diarrhea, and if treatment for identifiable microorganisms improves symptoms. Expand
Prevalence of Giardia lamblia and risk factors for infection among children attending day-care facilities in Denver.
A sample of children in the toddler age group was surveyed in Denver, CO, to determine the prevalence of Giardia lamblia and to identify risk factors for the intestinal disease. The sample consistedExpand
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