Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice.

@article{Rijli1995CryptorchidismAH,
  title={Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice.},
  author={Filippo M Rijli and Robert Matyas and Matteo Pellegrini and Andr{\'e}e Di{\'e}rich and P. Gruss and Pascal Doll{\'e} and Pierre Chambon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 18},
  pages={8185-9}
}
Homozygous mice mutated by homologous recombination for the AbdB-related Hoxa-10 gene are viable but display homeotic transformations of vertebrae and lumbar spinal nerves. Mutant males exhibit unilateral or bilateral criptorchidism due to developmental abnormalities of the gubernaculum, resulting in abnormal spermatogenesis and sterility. These results reveal an important role of Hoxa-10 in patterning posterior body regions and suggest that Hox genes are involved in specifying regional… CONTINUE READING