Cryptococcus neoformans enters the endolysosomal pathway of dendritic cells and is killed by lysosomal components.

@article{Wozniak2008CryptococcusNE,
  title={Cryptococcus neoformans enters the endolysosomal pathway of dendritic cells and is killed by lysosomal components.},
  author={Karen L. Wozniak and Stuart M Levitz},
  journal={Infection and immunity},
  year={2008},
  volume={76 10},
  pages={4764-71}
}
Cryptococcus neoformans is an opportunistic fungal pathogen that primarily causes disease in immunocompromised individuals. Dendritic cells (DCs) can phagocytose C. neoformans, present cryptococcal antigen, and kill C. neoformans. However, early events following C. neoformans phagocytosis by DCs are not well defined. We hypothesized that C. neoformans traffics to the endosome and the lysosome following phagocytosis by DCs and is eventually killed in the lysosome. Murine bone marrow-derived DCs… CONTINUE READING

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