Cryptococcus neoformans and cryptococcal glucuronoxylomannan, galactoxylomannan, and mannoprotein induce different levels of tumor necrosis factor alpha in human peripheral blood mononuclear cells.

@article{Chaka1997CryptococcusNA,
  title={Cryptococcus neoformans and cryptococcal glucuronoxylomannan, galactoxylomannan, and mannoprotein induce different levels of tumor necrosis factor alpha in human peripheral blood mononuclear cells.},
  author={Wendy Chaka and Andr{\'e} F. M. Verheul and V V Vaishnav and Robert Cherniak and Jelle Scharringa and J. C. Barendrecht Verhoef and Harm Wouter Snippe and I. M. Hoepelman},
  journal={Infection and immunity},
  year={1997},
  volume={65 1},
  pages={272-8}
}
Tumor necrosis factor alpha (TNF-alpha) release by peripheral blood mononuclear cells (PBMC) during disseminated infection by Cryptococcus neoformans may initiate and amplify the immune response of the host, leading to elimination of the fungus. The ability to induce TNF-alpha in PBMC by four clinical strains of C. neoformans, a laboratory strain (NIH 37), and the purified cryptococcal components glucuronoxylomannan (GXM), galactoxylomannan (GalXM), and mannoproteins (MP1 and MP2) were… CONTINUE READING

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