Cryptococcus neoformans STE12α Regulates Virulence but Is Not Essential for Mating

@article{Chang2000CryptococcusNS,
  title={Cryptococcus neoformans STE12α Regulates Virulence but Is Not Essential for Mating},
  author={Y. C. Chang and B. L. Wickes and G F Miller and L A Penoyer and K. J. Kwon-Chung},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={191},
  pages={871 - 882}
}
The Cryptococcus neoformans STE12alpha gene, a homologue of Saccharomyces cerevisiae STE12, exists only in mating type (MAT)alpha cells. In S. cerevisiae, STE12 was required for mating and filament formation. In C. neoformans, haploid fruiting on filament agar required STE12alpha. The ability to form hyphae, however, was not affected by deletion of… CONTINUE READING