Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 degrees C and in vivo.

@article{Kingsbury2004CryptococcusNI,
  title={Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 degrees C and in vivo.},
  author={Joanne M. Kingsbury and Zhonghui Yang and Tonya M. Ganous and Gary Matthew Cox and John H Mccusker},
  journal={Microbiology},
  year={2004},
  volume={150 Pt 5},
  pages={1547-58}
}
Acetolactate synthase catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors. The Cryptococcus neoformans ILV2 gene, encoding acetolactate synthase, was identified by complementation of a Saccharomyces cerevisiae ilv2 mutant. C. neoformans is highly resistant to the commercially available acetolactate synthase inhibitor, sulfometuron methyl (SM). Expression of C. neoformans ILV2 in S. cerevisiae conferred SM resistance… CONTINUE READING