Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole.

@article{EspinelIngroff2012CryptococcusNG,
  title={Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole.},
  author={Ana Victoria Espinel-Ingroff and Ana Isabel Aller and Emilia Cant{\'o}n and Laura Roc{\'i}o Casta{\~n}{\'o}n-Olivares and Anuradha Chowdhary and Susana C{\'o}rdoba and Manuel Cuenca-Estrella and Annette Fothergill and Jeff Fuller and Nevashan Govender and Ferry Hagen and Mar{\'i}a Teresa Illnait-Zaragoz{\'i} and Elizabeth Johnson and Sarah Kidd and Lass-Fl{\"o}rl Cornelia and Shawn R. Lockhart and Marilena dos Anjos Martins and Jacques F Meis and M{\'a}rcia de Souza Carvalho Melhem and Luis L Ostrosky-Zeichner and Teresa Pel{\'a}ez and Michael A. Pfaller and Wiley A. Schell and Guy St-Germain and Luciana Trilles and John D. Turnidge},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 11},
  pages={5898-906}
}
Epidemiological cutoff values (ECVs) for the Cryptococcus neoformans-Cryptococcus gattii species complex versus fluconazole, itraconazole, posaconazole, and voriconazole are not available. We established ECVs for these species and agents based on wild-type (WT) MIC distributions. A total of 2,985 to 5,733 CLSI MICs for C. neoformans (including isolates of molecular type VNI [MICs for 759 to 1,137 isolates] and VNII, VNIII, and VNIV [MICs for 24 to 57 isolates]) and 705 to 975 MICs for C. gattii… CONTINUE READING

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