Cryptococcus gattii in North American Pacific Northwest: Whole-Population Genome Analysis Provides Insights into Species Evolution and Dispersal

@inproceedings{Engelthaler2014CryptococcusGI,
  title={Cryptococcus gattii in North American Pacific Northwest: Whole-Population Genome Analysis Provides Insights into Species Evolution and Dispersal},
  author={David M Engelthaler and Nathan D. Hicks and John D. Gillece and Chandler C. Roe and James M. Schupp and Elizabeth M. Driebe and F{\'e}lix Gilgado and Fabian Carriconde and Luciana Trilles and Carolina Firacative and Popchai Ngamskulrungroj and E Casta{\~n}eda and M{\'a}rcia Dos Santos Laz{\'e}ra and Marcia S. C. Melhem and {\AA}sa P{\'e}rez-Bercoff and Gavin A. Huttley and Tania Christine Sorrell and Kerstin Voelz and Robin C May and Matthew C. Fisher and George R Thompson and Shawn R. Lockhart and Paul S Keim and Wieland Meyer},
  booktitle={mBio},
  year={2014}
}
The emergence of distinct populations of Cryptococcus gattii in the temperate North American Pacific Northwest (PNW) was surprising, as this species was previously thought to be confined to tropical and semitropical regions. Beyond a new habitat niche, the dominant emergent population displayed increased virulence and caused primary pulmonary disease, as opposed to the predominantly neurologic disease seen previously elsewhere. Whole-genome sequencing was performed on 118 C. gattii isolates… CONTINUE READING
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