Cryptococcosis in children with AIDS.

@article{Abadi1999CryptococcosisIC,
  title={Cryptococcosis in children with AIDS.},
  author={J. Abadi and S. Nachman and A. Kressel and L. Pirofski},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={1999},
  volume={28 2},
  pages={
          309-13
        }
}
  • J. Abadi, S. Nachman, +1 author L. Pirofski
  • Published 1999
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
We compiled the clinical and immunologic features of Cryptococcus neoformans infections in human immunodeficiency virus (HIV)-infected children from 1985 to 1996 in a retrospective case series. Thirty cases of cryptococcosis were identified. These children had a median age of 9.8 years, a median CD4+ cell count of 54/microL at the time of diagnosis, and either a culture positive for C. neoformans or cryptococcal antigen in serum or cerebrospinal fluid. Sixty-three percent of the cases occurred… Expand
Cryptococcosis in nonhuman immunodeficiency virus-infected children.
TLDR
Clinicians should take into account a diagnosis of central nervous system cryptococcosis when children present with prolonged headache, vomiting, and focal neurologic signs, and Indian ink stain and cryptococcal antigen testing of cerebrospinal fluid should be performed. Expand
Cryptococcosis in children.
TLDR
The purpose of this article is to discuss the aetiology, clinical presentation, predisposing conditions and outcomes in cases of cryptococcosis in children, with emphasis placed upon paediatric cases occuring in Brazil. Expand
Cryptococcosis in HIV-infected children.
TLDR
It is concluded that cryptococcal meningitis was the most common clinical presentation of cryptococcosis among HIV-infected children. Expand
Epidemiology of Cryptococcal Infection in Hospitalized Children
TLDR
The majority of pediatric cryptococcosis occurred in non–HIV-infected patients, but patients with non-CM were more likely to receive therapies not supported by these guidelines, and most patients had other immunocompromising medical conditions. Expand
Serologic evidence for Cryptococcus neoformans infection in early childhood.
TLDR
The results suggest that the low incidence of symptomatic cryptococcal disease in children with AIDS is not a result of lack of exposure to C neoformans, and provide both indirect and direct evidence of C neo formans infection in immunocompetent children. Expand
Analyses of Pediatric Isolates of Cryptococcus neoformans from South Africa
TLDR
Overall, these pediatric isolates exhibited high genotypic diversity, including a relatively large percentage of diploids and the rarely reported MAT a mating type, which is similar to those obtained from 86 adult patients during the same period. Expand
Cryptococcosis in Colombian children and literature review
TLDR
An epidemiological and clinical analysis was performed on cases of the disease observed in children less than 16 years old in Colombia between 1993-2010, which suggests that cryptococcosis in children is an unusual event worldwide. Expand
Fatal case of cryptococcal meningitis and pneumonia in HIV-infected child-case report
TLDR
While disease is not common in children, it remains an important cause of morbidity and mortality, and among pediatric patients incidence of cryptococcal meningitis relatively rare and reported in range 0,85-2,97%. Expand
Treatment Recommendations Treating Disease
  • 2020
Most cases of cryptococcosis in HIV-infected patients are caused by Cryptococcus neoformans; Cryptococcus gattii (formerly Cryptococcus neoformans variety gattii) infection occurs primarily inExpand
Cryptococcosis in Africa
TLDR
The epidemiology, diagnosis, clinical manifestations, treatment, and prognosis of cryptococcal disease in HAART-treated patients with paradoxical immune reconstitution inflammatory syndrome (IRIS), and the evolutionary relationships among African strains of Cryptococcus and their global ancestors are reviewed. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 20 REFERENCES
Cryptococcosis in human immunodeficiency virus-infected children.
TLDR
Cryptococcosis is an infrequent yet treatable opportunistic infection of advanced pediatric AIDS that may present with subtle manifestations and warrants careful consideration in the evaluation of febrile HIV-infected children. Expand
EXTRAPULMONARY CRYPTOCOCCOSIS IN CHILDREN WITH ACQUIRED IMMUNODEFICIENCY SYNDROME
TLDR
A spectrum of EC is indicated in pediatric human immunodeficiency virus infection ranging from fulminant, fatal fungemia to chronic meningitis and fever of unknown origin, including the role of fluconazole, warrants further study. Expand
Cryptococcal meningitis in patients with AIDS.
  • W. Dismukes
  • Biology, Medicine
  • The Journal of infectious diseases
  • 1988
The Cryptococcus has become a major cause of meningitis in patients infected with the human immunodeficiency virus (HIV), and the expression of cryptococcal infection in this population of patientsExpand
Cryptococcal meningitis and AIDS.
  • W. Powderly
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1993
TLDR
In this AIDS commentary Dr. William G. Powderly clearly outlines the progress made through clinical investigations and the problems that remain to be resolved about cryptococcal meningitis. Expand
Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome.
TLDR
It is concluded that the addition of flucytosine to amphotericin neither enhances survival nor prevents relapse, but long-term suppressive therapy appears to benefit these patients. Expand
Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Diagnostic features and outcome of treatment.
TLDR
It is suggested that maintenance therapy with amphotericin B may be needed to prevent relapse in patients with AIDS. Expand
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans
TLDR
Clinical concepts are presented that relate to the distinctive features of cryptococcosis in patients with AIDS and the diagnosis, treatment, and prevention of Cryptococcus neoformans in AIDS patients. Expand
Characteristics of human immunodeficiency virus-infected children at the time of death: an experience in the 1990s.
TLDR
Compared with children who died in 1990, HIV-infected children who die in 1996 were significantly older, more lymphopenic and more likely to have a greater number of organ system involvements and to have received antiviral therapy and antimicrobial prophylaxis. Expand
The ecology of Cryptococcus neoformans and the epidemiology of cryptococcosis.
  • S. Levitz
  • Biology, Medicine
  • Reviews of infectious diseases
  • 1991
TLDR
The ecology of Cryptococcus neoformans and the epidemiology of cryptococcosis are reviewed and it is presumed that most people can mount adequate host defenses upon exposure to the organism. Expand
Epidemiology of pediatric Human Immunodeficiency Virus infection in the United States
TLDR
If cases of HIV infection acquired from blood transfusions in the United States occurred before donor‐screening practices were implemented in March 1985, children born to HIV‐infected mothers will need to be identified early and monitored appropriately for CD4+ cell counts to determine the need for prophylaxis. Expand
...
1
2
...