Cryptococci at the brain gate: break and enter or use a Trojan horse?


The mechanism by which Cryptococcus neoformans invades the central nervous system is fundamental for understanding pathogenesis because cryptococcosis commonly presents as meningoencephalitis. There is evidence for both direct invasion of the endothelial cells lining the brain vasculature and a "Trojan horse" mechanism whereby cryptococci enter the central… (More)
DOI: 10.1172/JCI42949


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