Cryptococcal capsular glucuronoxylomannan reduces ischaemia-related neutrophil influx.

  title={Cryptococcal capsular glucuronoxylomannan reduces ischaemia-related neutrophil influx.},
  author={Pauline M. Ellerbroek and Regien Geertruida Schoemaker and Richard van Veghel and Andy I. M. Hoepelman and Frank E J Coenjaerts},
  journal={European journal of clinical investigation},
  volume={34 9},
BACKGROUND The capsular polysaccharide glucuronoxylomannan (GXM) of Cryptococcus neoformans interferes with the chemotaxis and transendothelial migration of neutrophils. Intravenous administration of purified GXM has been shown to reduce the influx of inflammatory cells in an animal model of bacterial infection. Here we show that isolated GXM can also interfere with neutrophil migration in a model of inflammation not related to infection. We assessed the effects of intravenous GXM on neutrophil… CONTINUE READING